Cassette Beasts (60 FPS):
Fullscreen -> On
Resolution -> 1280x800
Frame Rate -> 60
Graphics Preset -> Custom
Antialiasing -> Disabled
DOF Blur -> Off
Glow -> On
Overworld Shadows -> On or Off [Battery Saver]
Overworld Streaming -> Less Pop-In
Glitch Effects -> Enabled
Color Blind Mode -> Off
(!: With MSAA anti-aliasing enabled, pixel art styles become blurry; settings marked as “Battery Saver” can be turned off, which can yield more battery life without compromising the visual aspect of the game.)
You can also drop the GPU clock speed and power watt down a bit. You still get locked 60fps but with zero fan noise and 6 hours of gameplay.
Yes, I left it to the end user to do it themselves so they could find their sweet spot.