All the time in programming. Jump to the start/end of the line, quickly scrolling through logfiles, source files, documentation etc.

Yes, most of them can probably be replaced by some other key combination. But it will be a different shortcut for each tool, and I don’t feel like remembering multiple combinations just to navigate a file using a keyboard.

Missing home/ end/ PgUp/ down keys is actually the biggest reason why I still haven’t bought one. I just don’t want to take the risk.